3-isobutylglutaric anhydride
- Name 3-isobutylglutaric anhydride
- CAS 185815-59-2
- Purity 99%
Product Details
Top Quality Chinese Manufacturer supply 185815-59-2 3-isobutylglutaric anhydride
- Molecular Formula: C9H14O3
- Molecular Weight: 170.208
- Vapor Pressure: 0.00406mmHg at 25°C
- Refractive Index: 1.451
- Boiling Point: 279.3 °C at 760 mmHg
- Flash Point: 124 °C
- PSA： 43.37000
- Density: 1.054 g/cm3
- LogP: 1.51230
3-isobutylglutaric anhydride(Cas 185815-59-2) Usage
InChI:InChI=1/C9H14O3/c1-6(2)3-7-4-8(10)12-9(11)5-7/h6-7H,3-5H2,1-2H3
185815-59-2 Relevant articles
Pregabalin intermittent synthesis method
-
Paragraph 0014; 0019, (2019/02/21)
The invention discloses a pregabalin int...
Method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid
-
Paragraph 0019; 0021; 0025; 0028; 0032, (2019/09/14)
The invention relates to the technical f...
Asymmetrical synthesis method of lyrica
-
Paragraph 0013; 0030-0032; 0039-0041; 0050, (2018/06/04)
The invention discloses an asymmetrical ...
Method for preparing Pregabalin intermediate
-
Page/Page column 5-9, (2019/01/06)
The invention provides a method for prep...
185815-59-2 Process route
-
-
75143-89-4
5-methyl-3-carboxymethylhexanoic acid
-
-
185815-59-2
3-isobutylglutaric anhydride
| Conditions | Yield |
|---|---|
|
With
propionic acid anhydride;
at 140 - 145 ℃;
for 6h;
|
91%
|
|
With
acetyl chloride;
at 20 - 55 ℃;
for 3.08333h;
Inert atmosphere;
|
85%
|
|
at 150 ℃;
unter vermindertem Druck;
|
|
|
With
acetic anhydride;
at 135 - 145 ℃;
for 2.5 - 3h;
|
|
|
With
thionyl chloride;
for 0.5h;
Heating / reflux;
|
|
|
With
acetic anhydride;
|
|
|
With
acetyl chloride;
at 60 ℃;
for 3h;
|
|
|
With
phosphorus pentoxide;
at 95 ℃;
for 3h;
Temperature;
|
|
|
With
acetic anhydride;
at 120 ℃;
for 2h;
|
|
|
With
acetic anhydride;
at 130 - 140 ℃;
for 3h;
|
|
|
With
acetic anhydride;
at 135 - 145 ℃;
Temperature;
Industrial scale;
|
9 kg
|
|
With
acetic anhydride;
at 130 ℃;
for 3h;
|
|
|
With
acetic anhydride;
for 2.5h;
Reflux;
|
|
|
In
acetic anhydride;
at 20 ℃;
|
-
-
590-86-3
isovaleraldehyde
-
-
107-91-5
cyanoacetic acid amide
-
-
185815-59-2
3-isobutylglutaric anhydride
| Conditions | Yield |
|---|---|
|
isovaleraldehyde; cyanoacetic acid amide;
piperidine;
In
dichloromethane; water;
at 22 - 25 ℃;
for 6h;
With
hydrogenchloride;
In
water;
for 20h;
Heating;
With
acetic anhydride;
for 2h;
Further stages.;
Heating;
|
65%
|
185815-59-2 Upstream products
-
75143-89-4
5-methyl-3-carboxymethylhexanoic acid
-
590-86-3
isovaleraldehyde
-
107-91-5
cyanoacetic acid amide
-
51615-30-6
diethyl 2-(3-methylbutylidene)malonate
185815-59-2 Downstream products
-
181289-25-8
(3S)-3-(2-methoxy-2-oxoethyl)-5-methylhexanoic acid
-
959624-21-6
(S)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid
-
1057113-78-6
(R)-4-(((S)-carboxy(phenyl)methoxy)carbonyl)-3-isobutylbutanoic acid
-
181289-33-8
(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
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