Imatinib

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1.What is the Imatinib ?

Imatinib, also known as Gleevec, Glivec, CGP-57148B, STI-571, and Imatinib Mesylate, is an orally bioavailable mesylate salt that functions as a multi-target inhibitor of v-Abl, c-Kit, and PDGFR. It is characterized by its orange solid appearance and is primarily used in the treatment of various cancers and disorders.

Imantinib mesylate (Gleevec) is a rationally designed inhibitor of the tumor-specific bcr-abl kinase. The Philadelphia chromosome, present in nearly all patients with chronic myelogenous leukemia (CML), is produced by a chromosomal rearrangement linking the bcr and the abl genes. The bcr-able kinase is therefore a unique drug target in leukemic cells, and imantinib selectively and potently inhibits this kinase. Remissions in CML patients are achieved with high frequency and very low toxicity, and Imatinib may become a front-line agent for treating this cancer. Unfortunately, drug resistance has already been observed in the clinic as a result of mutations in the bcr-abl kinase, and this magic bullet does not appear to be curative for CML patients. Extension of the use of imantinib to other tumor types with overexpression of c-kit kinase or platelet-derived growth factor kinase is undergoing development because of its observed activity against these kinases.

Imatinib impurity.

2.What is the CAS number for Imatinib ?

The CAS number of Imatinib is 152459-95-5.

More information of Imatinib 152459-95-5 are:

3.What is the molecular formula of Imatinib ?

The chemical formula of?Imatinib is C29H31N7O which containing 29 Carbon atoms,31 Hydrogen atoms,7 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of Imatinib is 493.611

4.What is Imatinib(152459-95-5)used for?

Imatinib, also known as Gleevec, Glivec, CGP-57148B, STI-571, and Imatinib Mesylate, is an orally bioavailable mesylate salt that functions as a multi-target inhibitor of v-Abl, c-Kit, and PDGFR. It is characterized by its orange solid appearance and is primarily used in the treatment of various cancers and disorders.

InChI:InChI=1/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)

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5.High quality purity >99% Imatinib 152459-95-5 for sale

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