Offer Chemical Raw Material (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one 6902-91-6 In Stock

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1.What is the (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one ?

Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.

: 37905-03-6
8-hydroxygeranyl acetate

: 6902-91-6
germacrone

Conditions

Conditions	Yield
Multi-step reaction with 13 steps 2: 65 percent / triphenylphosphine / palladium acetate / tetrahydrofuran / 5 h / Heating 3: 95 percent / sodium hydride / diethyl ether / 0 °C 4: 70 percent / diethyl ether / -10 °C 5: 90 percent / triphenylphosphine, carbon tetrachloride / 12 h / Heating 6: diisobutylaluminium hydride / tetrahydrofuran / -40 °C 7: manganese dioxide / hexane / Ambient temperature 8: KCN, 18-crown-6 / 1 h / 0 °C 9: trimethylbenzylammonium fluoride / tetrahydrofuran; H₂O / 0 °C 11: 79 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / 56 °C 12: p-toluenesulfonic acid / methanol / 1 h / 0 °C 13: 2percent aqueous sodium hydroxide / diethyl ether / 0.33 h With tetrachloromethane; potassium cyanide; manganese(IV) oxide; sodium hydroxide; 18-crown-6 ether; sodium hexamethyldisilazane; trimethyl(benzyl)ammonium fluoride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; water;

Yield

Multi-step reaction with 13 steps

2: 65 percent / triphenylphosphine / palladium acetate / tetrahydrofuran / 5 h / Heating

3: 95 percent / sodium hydride / diethyl ether / 0 °C

4: 70 percent / diethyl ether / -10 °C

5: 90 percent / triphenylphosphine, carbon tetrachloride / 12 h / Heating

6: diisobutylaluminium hydride / tetrahydrofuran / -40 °C

7: manganese dioxide / hexane / Ambient temperature

8: KCN, 18-crown-6 / 1 h / 0 °C

9: trimethylbenzylammonium fluoride / tetrahydrofuran; H₂O / 0 °C

11: 79 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / 56 °C

12: p-toluenesulfonic acid / methanol / 1 h / 0 °C

13: 2percent aqueous sodium hydroxide / diethyl ether / 0.33 h

With tetrachloromethane; potassium cyanide; manganese(IV) oxide; sodium hydroxide; 18-crown-6 ether; sodium hexamethyldisilazane; trimethyl(benzyl)ammonium fluoride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; water;

: 87064-43-5
Acetic acid (2E,6E)-8-(1-ethoxy-ethoxy)-3,7-dimethyl-octa-2,6-dienyl ester

: 6902-91-6
germacrone

Conditions

Conditions	Yield
Multi-step reaction with 12 steps 1: 65 percent / triphenylphosphine / palladium acetate / tetrahydrofuran / 5 h / Heating 2: 95 percent / sodium hydride / diethyl ether / 0 °C 3: 70 percent / diethyl ether / -10 °C 4: 90 percent / triphenylphosphine, carbon tetrachloride / 12 h / Heating 5: diisobutylaluminium hydride / tetrahydrofuran / -40 °C 6: manganese dioxide / hexane / Ambient temperature 7: KCN, 18-crown-6 / 1 h / 0 °C 8: trimethylbenzylammonium fluoride / tetrahydrofuran; H₂O / 0 °C 10: 79 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / 56 °C 11: p-toluenesulfonic acid / methanol / 1 h / 0 °C 12: 2percent aqueous sodium hydroxide / diethyl ether / 0.33 h With tetrachloromethane; potassium cyanide; manganese(IV) oxide; sodium hydroxide; 18-crown-6 ether; sodium hexamethyldisilazane; trimethyl(benzyl)ammonium fluoride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; water;

Yield

Multi-step reaction with 12 steps

1: 65 percent / triphenylphosphine / palladium acetate / tetrahydrofuran / 5 h / Heating

2: 95 percent / sodium hydride / diethyl ether / 0 °C

3: 70 percent / diethyl ether / -10 °C

4: 90 percent / triphenylphosphine, carbon tetrachloride / 12 h / Heating

5: diisobutylaluminium hydride / tetrahydrofuran / -40 °C

6: manganese dioxide / hexane / Ambient temperature

7: KCN, 18-crown-6 / 1 h / 0 °C

8: trimethylbenzylammonium fluoride / tetrahydrofuran; H₂O / 0 °C

10: 79 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / 56 °C

11: p-toluenesulfonic acid / methanol / 1 h / 0 °C

12: 2percent aqueous sodium hydroxide / diethyl ether / 0.33 h

With tetrachloromethane; potassium cyanide; manganese(IV) oxide; sodium hydroxide; 18-crown-6 ether; sodium hexamethyldisilazane; trimethyl(benzyl)ammonium fluoride; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; hexane; water;

2.What is the CAS number for (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one ?

The CAS number of (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one is 6902-91-6.

More information of (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one 6902-91-6 are:

CAS?Number	6902-91-6
Density	0.916 g/cm³
Melting Point	55-58 °C
Boiling Point	330.274 °C at 760 mmHg
Flash Point	148.419 °C
Vapor Pressure	0.000168mmHg at 25°C
Refractive Index	1.485
HS CODE	29142990
PSA	17.07000
LogP	4.35850

3.What are another words for (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one ?

Synonyms?for?(3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one 6902-91-6:3,7-Cyclodecadien-1-one,3,7-dimethyl-10-(1-methylethylidene)-, (E,E)-;Germacra-3,7(11),9-trien-6-one,(E,E)- (8CI);Germacrone (6CI,7CI);(E,E)-Germacrone;Germacron;

4.What is the molecular formula of (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one?

The chemical formula of ?(3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one is?C15H22O which containing 15 Carbon atoms,22 Hydrogen atoms and 1 Oxygen atoms,and the molecular weight of??(3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one?is 218.339.

5.What is (3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one (6902-91-6) used for?

Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities. It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 μM. Germacrone (50-250 μM) enhances cytotoxicity and apoptosis induced by doxorubicin in doxorubicin-resistant MCF-7/adr cells. In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity. It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).

InChI:InChI=1/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7+

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(3Z,7Z)-3,7-Dimethyl-10-propan-2-ylidene-cyclodeca-3,7-dien-1-one