102767-28-2
- Name 102767-28-2
- CAS 102767-28-2
- Purity 99%
Product Details
Quality products?make an important contribution to long-term revenue and profitability. Top Quality 102767-28-2 102767-28-2 Hot Sell In Stock
1.What is the 102767-28-2 ?
Approximately 50 million people worldwide are affected by epilepsy. [3]
Levetiracetam was approved by the US FDA in November 1999 as add-on therapy for the treatment of partial-onset seizures in adults (age 16 years and older). Levetiracetam is a Pregnancy Category C drug. Overall, when used in combination with other AEDs, levetiracetam was generally well tolerated as add-on treatment for partial-onset seizures.[1]
Levetiracetam (LEV) stands out from other AEDs due to its novel and main mechanism of action through the interaction with the synaptic vesicle protein 2A (SV2A) [3]
.
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102849-49-0
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
-
-
102767-28-2
levetiracetam
| Conditions | Yield |
|---|---|
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid;
With
thionyl chloride;
In
methanol;
at 45 ℃;
With
ammonia;
In
methanol;
at 20 ℃;
under 2250.23 Torr;
Product distribution / selectivity;
|
78.4%
|
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid;
With
chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
ammonium hydroxide;
In
tetrahydrofuran;
for 16h;
|
75%
|
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid;
With
ammonium hydroxide; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
ammonium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 11h;
|
72%
|
|
With
ammonium hydroxide; chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 12.5h;
|
65%
|
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid;
With
chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
With
ammonium hydroxide;
In
tetrahydrofuran;
at 0 - 20 ℃;
enantioselective reaction;
|
62%
|
|
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid;
With
di-tert-butyl dicarbonate;
In
acetonitrile;
at 10 - 15 ℃;
With
pyridine; ammonium bicarbonate;
In
acetonitrile;
at 10 - 20 ℃;
|
|
|
Multi-step reaction
with
2
steps
1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2: ammonium hydroxide / water; tetrahydrofuran / 18.5 h / 0 - 20 °C / Inert atmosphere
With
ammonium hydroxide; triethylamine;
In
tetrahydrofuran; water;
|
-
-
102916-46-1
(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt
-
-
102767-28-2
levetiracetam
| Conditions | Yield |
|---|---|
|
(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt;
With
sodium hydroxide;
In
water;
for 0.5h;
With
chloroformic acid ethyl ester;
In
dichloromethane;
at -10 ℃;
for 2h;
With
ammonia;
In
dichloromethane;
at -15 - -10 ℃;
for 2h;
Solvent;
Reagent/catalyst;
|
85%
|
|
Multi-step reaction
with
3
steps
1.1: sodium hydroxide; water / 0.5 h / 0 - 10 °C
1.2: pH 4 - 5
2.1: toluene-4-sulfonic acid / 7 h / 60 °C
3.1: ammonia / 24 h / 0 - 10 °C
With
ammonia; water; toluene-4-sulfonic acid; sodium hydroxide;
|
2.What is the CAS number for 102767-28-2 ?
The CAS number of 102767-28-2 is 102767-28-2.
More information of 102767-28-2 102767-28-2 are:
|
CAS?Number |
102767-28-2 |
|
Density |
1.168 g/cm3 |
|
Melting Point |
118-119 °C |
|
Boiling Point |
395.9 °C at 760 mmHg |
|
Flash Point |
193.2 °C |
|
Vapor Pressure |
1.78E-06mmHg at 25°C |
|
Refractive Index |
1.518 |
|
HS CODE |
2933990090 |
|
PSA |
63.40000 |
|
LogP |
0.51090 |
3.What are another words for 102767-28-2 ?
Synonyms?for?102767-28-2 102767-28-2:2-(2-oxopyrrolidin-1-yl)butanamide;Keppra (TN);1-Pyrrolidineacetamide,R-ethyl-2-oxo-,(RS)-;Levetiracetamum [INN-Latin];(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide;(2R)-2-(2-oxopyrrolidin-1-yl)butanamide;(2S)-2-(2-oxopyrrolidin-1-yl)butanamide;UCB-L 059;Levetiracetam [INN];Keppra;1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-, (S)-;Levetiracetam butanamide;
4.What is the molecular formula of 102767-28-2?
The chemical formula of ?102767-28-2 is?C8H14N2O2 which containing 8 Carbon atoms,14 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??102767-28-2?is 170.211.
5.What is 102767-28-2 (102767-28-2) used for?
102767-28-2, also known as Resmethrin, is a synthetic pyrethroid insecticide and acaricide used for controlling a wide range of household and agricultural pests. It is commonly formulated as an aerosol spray or fogger for indoor pest control and is effective against mosquitoes, flies, ants, and cockroaches. Resmethrin works by disrupting the function of the nervous system in insects, leading to paralysis and death. It is generally considered to have low toxicity to humans and other mammals when used according to label instructions.
InChI:InChI=1/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
Relevant articles related to 102767-28-2:
|
Article |
Source |
|
Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams |
Cioc, R?zvan C.,Schaepkens van Riempst, Lola,Schuckman, Peter,Ruijter, Eelco,Orru, Romano V. A. , p. 1664 - 1674 (2017) |
|
Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals |
Song, Lixing,Shemchuk, Oleksii,Robeyns, Koen,Braga, Dario,Grepioni, Fabrizia,Leyssens, Tom , p. 2446 - 2454 (2019) |
6.Buy 102767-28-2 with the best price .
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