2-Amino-4-(trifluoromethyl)pyridine
- Name 2-Amino-4-(trifluoromethyl)pyridine
- CAS 106447-97-6
- Purity 99%
Product Details
Factory supply good quality 2-Amino-4-(trifluoromethyl)pyridine 106447-97-6 with stock
- Molecular Formula: C6H5F3N2
- Molecular Weight: 162.114
- Vapor Pressure: 0.108mmHg at 25°C
- Melting Point: 70-74 °C
- Refractive Index: 1.479
- Boiling Point: 221.338 °C at 760 mmHg
- PKA: 4.55±0.11(Predicted)
- Flash Point: 87.662 °C
- PSA： 38.91000
- Density: 1.368 g/cm3
- LogP: 2.26380
2-Amino-4-(trifluoromethyl)pyridine(Cas 106447-97-6) Usage
|
Synthesis |
2-Amino-4-(trifluoromethyl)pyridine can be synthesized by chemical reaction of 2-fluoro-4-trifluoromethyl-pyridine, acetamidine hydrochloride, NaOH, H2O and dimethyl sulfoxide under certain conditions. |
InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-1-2-11-5(10)3-4/h1-3H,(H2,10,11)
106447-97-6 Relevant articles
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms
Webber, R. Keith,Metz, Suzanne,Moore, William M.,Connor, Jane R.,Currie, Mark G.,Fok, Kam F.,Hagen, Timothy J.,Hansen Jr., Donald W.,Jerome, Gina M.,Manning, Pamela T.,Pitzele, Barnett S.,Toth, Mihaly V.,Trivedi, Mahima,Zupec, Mark E.,Siong Tjoeng
, p. 96 - 101 (1998)
A series of analogues of 2-iminopiperidi...
Nucleophilic displacement in 2-chloro(trifluoromethyl)pyridines with amines and ammonia
Dunn
, p. 153 - 157 (1999)
The activating effect of trifluoromethyl...
Preparation method of 2-amino substituted six-membered nitrogen-containing heterocycle complex
-
Paragraph 0025; 0026; 0095, (2019/02/08)
The invention discloses a preparation me...
Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride
Li, Yibiao,Huang, Shuo,Liao, Chunshu,Shao, Yan,Chen, Lu
supporting information, p. 7564 - 7567 (2018/11/02)
Under catalyst-free conditions, an effic...
METHOD FOR PRODUCING 2-AMINO-4-(TRIFLUOROMETHYL)PYRIDINE
-
Page/Page column 6-7, (2012/12/13)
The present invention relates to a proce...
METHOD OF INHIBITING HAMARTOMA TUMOR CELLS
-
Page/Page column 20, (2012/08/28)
Dimorpholinopyrimidines are useful for i...
106447-97-6 Process route
-
-
39890-98-7
2,6-dichloro-4-(trifluoromethyl)pyridine
-
-
130171-52-7
4-(trifluoromethyl)pyridine-2,6-diamine
-
-
106447-97-6
2-amino-4-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
2,6-dichloro-4-(trifluoromethyl)pyridine;
With
ammonia;
In
water;
at 150 ℃;
for 15h;
autoclave;
With
hydrogen;
5%-palladium/activated carbon;
In
water;
at 100 ℃;
for 3h;
under 13501.4 Torr;
|
-
-
917806-22-5
5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile
-
-
106447-97-6
2-amino-4-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
|
With
ammonia;
In
water;
at 125 ℃;
for 24h;
under 10501.1 Torr;
Autoclave;
|
68%
|
106447-97-6 Upstream products
-
81565-18-6
2-chloro-4-trifluoromethyl pyridine
-
22253-59-4
1-oxido-4-(trifluoromethyl)pyridin-1-ium
-
944401-56-3
2-amino-5-bromo-4-(trifluoromethyl)pyridine
-
73183-34-3
bis(pinacol)diborane
106447-97-6 Downstream products
-
50650-59-4
4-(trifluoromethyl)-2-pyridone
-
121307-79-7
4-trifluoromethylpyridine-2(1H)-thione
-
857265-11-3
phenyl N-[4-(trifluoromethyl)pyridin-2-yl]carbamate
-
944401-56-3
2-amino-5-bromo-4-(trifluoromethyl)pyridine
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